NKG2D Blockade Prevents Autoimmune Diabetes in NOD Mice
2004; Cell Press; Volume: 20; Issue: 6 Linguagem: Inglês
10.1016/j.immuni.2004.05.008
ISSN1097-4180
AutoresKouetsu Ogasawara, Jessica A. Hamerman, Lauren I. R. Ehrlich, H Bour, Pere Santamaría, Jeffrey A. Bluestone, Lewis L. Lanier,
Tópico(s)Pancreatic function and diabetes
ResumoNKG2D is an activating receptor on CD8+ T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8+ T cells infiltrating the pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody (mAb) during the prediabetic stage completely prevented disease by impairing the expansion and function of autoreactive CD8+ T cells. These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes.
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