Inactivation of dry enzymes and viruses by energetic heavy ions
1987; Elsevier BV; Volume: 30; Issue: 3 Linguagem: Inglês
10.1016/1359-0197(87)90081-6
ISSN1878-1020
AutoresM.P.R. Waligórski, Kim Sun Loh, Robert Katz,
Tópico(s)Radiation Therapy and Dosimetry
ResumoA newly developed corrected formula for the distribution of dose (RDD) has been used to calculate cross sections for the inactivation of dry enzymes and viruses by heavy ranging from 42He to 4018Ar of energies ca 10 MeV/a.m.u., spanning a range of LET of ca 5–2000 MeV cm2g-1. In comparison with earlier “point-target” calculaions of Butts and Katz where a linear range-energy relationship for electrons (σ-rays) was used, and with “extended-target” calculations of Zhang Dunn and Katz where a power range-energy law and an “uncorrected” RDD formula were applied, the present calculations reproduce all the 72 experimentally measured cross sections and values of the D-37 dose (where available) much more accurately, essentially to within experimental errors. This agreement supports the validity of our phenomenological correction of the RDD formula, suggesting that the theory should rather be tested in the highly structured “thindown” region, at ion energies below ca 0.5 MeV/a.m.u.
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