Preparative supercritical deuterium exchange in arenes and heteroarenes
1996; Elsevier BV; Volume: 37; Issue: 20 Linguagem: Inglês
10.1016/0040-4039(96)00615-6
ISSN1873-3581
AutoresThomas Junk, W. James Catallo,
Tópico(s)Mass Spectrometry Techniques and Applications
ResumoDeuterated homo- and heterocyclic aromatic substrates bearing various functionalities were prepared by isotope exchange in supercritical deuterium oxide, with little or no formation of byproducts. Equilibration was attained rapidly (1 – 24 hrs), and deuterium exchange extended to alpha positions of alkyl homologs. Nitro- and haloarenes, thioethers, telluroethers, and some heterocyclic substrates were unstable.
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