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42 Phase II study of BAY 43-9006 in patients with advanced hepatocellular carcinoma (HCC)

2004; Elsevier BV; Volume: 2; Issue: 8 Linguagem: Inglês

10.1016/s1359-6349(04)80050-8

1878-1217

G. K. Abou-Alfa, Stefano Ricci, D. Amadori, Armando Santoro, Arié Figer, Jacques De Grève, Jean‐Yves Douillard, M. Moscovici, Brian Schwartz, Leonard B. Saltz,

Cell Adhesion Molecules Research

Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the past three years, three types of scaffolds for GPCR-directed complex assembly have been identified: transactivated receptor tyrosine kinases (RTKs), integrin-based focal adhesions, and GPCRs themselves. Nonreceptor tyrosine kinases play an important role in each case. The processes of GPCR desensitization and sequestration via clathrin-coated pits are also involved in signaling through the RTK- and GPCR-based scaffolds.