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Catalytic Enantioselective Reduction of β,β‐Disubstituted Vinyl Phenyl Sulfones by Using Bisphosphine Monoxide Ligands

2007; Wiley; Volume: 46; Issue: 31 Linguagem: Inglês

10.1002/anie.200701367

1521-3773

Jean‐Nicolas Desrosiers, André B. Charette,

Asymmetric Synthesis and Catalysis

Synthesis of chiral sulfones: A copper–phosphine complex efficiently provided optically active alkyl phenyl sulfones by hydrosilylation at room temperature. The reduction of β,β-disubstituted vinyl sulfones in the presence of the Me-DuPhos monoxide ligand lead to excellent enantiomeric excesses and high yields (see scheme). The prepared chiral sulfones were desulfonylated and subjected to Julia olefination conditions.