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Human neuroblastoma stem cells

2006; Elsevier BV; Volume: 17; Issue: 3 Linguagem: Inglês

10.1016/j.semcancer.2006.04.006

1096-3650

Robert A. Ross, Barbara A. Spengler,

Cancer Cells and Metastasis

Human neuroblastoma is an embryonic cancer of the neural crest. Cellular heterogeneity is a characteristic feature of both tumors and derived cell lines. Recent studies have revealed that both cell lines and tumors contain cancer stem cells. In culture, these cells are self-renewing, multipotent, and highly malignant; in tumors their frequency correlates with a worse prognosis. Their identification and characterization should now permit a targeted approach to more effective treatment of this often fatal childhood cancer.