Produção Nacional
Revisado por pares
Photocatalytic degradation of rosuvastatin: Analytical studies and toxicity evaluations
2014; Elsevier BV; Volume: 502; Linguagem: Inglês
10.1016/j.scitotenv.2014.09.076
ISSN1879-1026
AutoresTiele Caprioli Machado, Tânia Mara Pizzolato, Alexandre Arenzon, Jéferson Segalin, Marla Azário Lansarin,
Tópico(s)TiO2 Photocatalysis and Solar Cells
ResumoPhotocatalytic degradation of rosuvastatin, which is a drug that has been used to reduce blood cholesterol levels, was studied in this work employing ZnO as catalyst. The experiments were carried out in a temperature-controlled batch reactor that was irradiated with UV light. Preliminary the effects of the photocatalyst loading, the initial pH and the initial rosuvastatin concentration were evaluated. The experimental results showed that rosuvastatin degradation is primarily a photocatalytic process, with pseudo-first order kinetics. The byproducts that were generated during the oxidative process were identified using nano-ultra performance liquid chromatography tandem mass spectrometry (nano-UPLC–MS/MS) and acute toxicity tests using Daphnia magna were done to evaluate the toxicity of the untreated rosuvastatin solution and the reactor effluent.
Referência(s)