Produção Nacional
Revisado por pares
Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan
2012; Hindawi Publishing Corporation; Volume: 2013; Linguagem: Inglês
10.1155/2013/640682
ISSN2314-6141
AutoresFernando Gomes Figueredo, Emerson O. Ferreira, Bruno F. F. Lucena, Cícero Magérbio Gomes Torres, Daniel Luna Lucetti, Elaine Cristina Pereira Lucetti, João Marcos F. L. Silva, Francisco Antônio Vieira dos Santos, Cássio Rocha Medeiros, Gardênia M. M. Oliveira, Aracélio Viana Colares, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Júlio C. F. Silva, Marta Regina Kerntopf, Patrícia Rosane Leite de Figueiredo, Edinardo Fágner Ferreira Matias,
Tópico(s)Ethnobotanical and Medicinal Plants Studies
ResumoThe aim of this study was to verify the possible interactions between ethanol extracts of Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan, combined with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli isolated from humans. The antibacterial activity of the extracts was determined using the minimum inhibitory concentration (MIC). The microdilution assay was performed to verify the interactions between the natural products and the antibiotics using a subinhibitory concentration. The activity of amikacin associated with the extract of Anadenanthera macrocarpa against EC 27 was enhanced, demonstrating an MIC reduction from 128 to 4 μ g/mL. Among the β -lactams, no potentiation on its activity was observed, with exception to the antagonism of the natural products with ampicillin against S. aureus 358.
Referência(s)