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Natural Saline-Flush Is Sufficient to Maintain Patency of Immobilized-Urokinase Double-Lumen Catheter Used to Provide Temporary Blood Access for Hemodialysis

2004; Karger Publishers; Volume: 22; Issue: 5 Linguagem: Inglês

10.1159/000081811

1421-9735

Yoshikatsu Kaneko, Masako Iwano, Hitomi Yoshida, Miyoko Kosuge, Sanae Ito, Ichiei Narita, Fumitake Gejyo, Masashi Suzuki,

Cardiac Arrhythmias and Treatments

Thrombotic occlusion is a frequent complication of central venous catheters used to provide temporary blood access on hemodialysis therapy. Heparin-lock is conventionally used to maintain patency of the catheter, but the necessity of heparin-lock has not been determined yet.After the immobilized-urokinase double-lumen central venous catheter was inserted into 48 Japanese hemodialysis patients, 22 patients randomized to the heparin group received a 20-ml saline-flush, followed by 2 ml of 1,000 U/ml heparin-lock, and 26 patients randomized to the saline group received only the 20-ml saline-flush once a day for each lumen.Thrombotic occlusion was observed in only 1 out of 22 patients in the heparin group and 1 out of 26 patients in the saline group. No significant difference of the catheter survival was observed between the two groups (p = 0.8599).Natural saline-flush is sufficient for maintaining the patency of an immobilized-urokinase double-lumen central venous catheter.