Screening for mitochondrial cytopathies: the sub-anaerobic threshold exercise test (SATET).
1989; BMJ; Volume: 52; Issue: 9 Linguagem: Inglês
10.1136/jnnp.52.9.1090
ISSN1468-330X
Autores Tópico(s)Glycogen Storage Diseases and Myoclonus
ResumoA simple test is described for identifying patients with abnormalities of muscle energy metabolism secondary to mitochondrial dysfunction, based on the venous lactate response to exercise at 90% of predicted work rate at the anaerobic threshold. The test was standardised for age, weight and sex of subjects, and was abnormal in all cases of mitochondrial cytopathy tested, with a false positive rate of 7% in a control population. The test was abnormal in two cases of mitochondrial disease in which muscle biopsy was normal or showed only non-specific changes.
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