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Clinical outcomes of patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae after treatment with imipenem or meropenem

2009; Elsevier BV; Volume: 64; Issue: 2 Linguagem: Inglês

10.1016/j.diagmicrobio.2009.02.004

1879-0070

Scott A. Weisenberg, Daniel J. Morgan, Rosanny Espinal-Witter, Davise H. Larone,

Antibiotics Pharmacokinetics and Efficacy

Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae may appear susceptible to imipenem or meropenem by routine susceptibility testing. We report a series of patients with infections caused by K. pneumoniae isolates, which yielded imipenem-susceptible results but were subsequently KPC-positive by polymerase chain reaction. When these infections were treated with imipenem or meropenem, frequent clinical and microbiologic failures were observed.