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Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells

2005; Elsevier BV; Volume: 14; Issue: 1 Linguagem: Inglês

10.1016/j.bmc.2005.08.005

1464-3391

Đặng Ngọc Quang, Toshihiro Hashimoto, Yuuki Arakawa, Chie Kohchi, Takashi Nishizawa, Gen‐Ichiro Soma, Yoshinori Asakawa,

Nitric Oxide and Endothelin Effects

Two new farnesyl phenols named grifolinones A and B, together with known grifolin and neogrifolin, were isolated from methanolic extract of the inedible mushroom Albatrellus caeruleoporus. Their structures were characterized by a combination of 2D NMR, MS, IR, and UV spectra. Grifolinone B was composed of two grifolin molecules, which were connected by a C–C bond. Grifolinones A and B, grifolin, and neogrifolin exhibited inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with IC50 values of 23.4, 22.9, 29.0, and 23.3 μM, respectively.