The role of the mitochondrial permeability transition in cell death
2006; Elsevier BV; Volume: 6; Issue: 5 Linguagem: Inglês
10.1016/j.mito.2006.07.006
ISSN1872-8278
Autores Tópico(s)ATP Synthase and ATPases Research
ResumoThe mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that occurs in response to increased calcium load and redox stress. Currently, two models of the MPT exist including the, largely hypothetical, native proteinaceous pore model and the oxidized inner membrane protein model which may reflect the extremes in a continuum of changes that occur to the inner membrane prior to its permeabilization. Here I discuss evidence that the MPT per se leads to necrosis, but not cytochrome c release and apoptosis. However, data also suggest that signaling crosstalk between the MPT and Bcl-2 family proteins occurs indicating an important role for the MPT in apoptosis.
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