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The first enantioselective synthesis of 4-acetyl-3( R) - and 3( S )-(hydroxymethyl)-3,4-dihydro-2 H -pyrido[3,2- b ]oxazine

2004; Elsevier BV; Volume: 45; Issue: 7 Linguagem: Inglês

10.1016/j.tetlet.2003.12.030

1873-3581

Neil Henry, Gérald Guillaumet, M. Dolors Pujol,

Phytochemistry and Bioactivity Studies

Abstract A novel short and enantioselective synthetic approach to pyridobenzoxazines is reported in which ( R )- and ( S )-3-(hydroxymethyl)-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]oxazine were first synthesized from readily available chiral glycidyl derivatives.