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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Molecular shape of dystrophin purified from rabbit skeletal muscle myofibrils.

1990; Japan Academy; Volume: 66; Issue: 5 Linguagem: Inglês

10.2183/pjab.66.96

ISSN

1349-2896

Autores

Takashi Murayama, Osamu Satō, Sumiko Kimura, Teruo Shimizu, Hajime Sawada, Kosçak Maruyama,

Tópico(s)

Adipose Tissue and Metabolism

Resumo

Dystrophin, the product of Duchenne muscular dystrophy (DMD) gene, was purified to 70-80% homogeneity from rabbit skeletal muscle myofibrils by hydroxylapatite, wheat germ agglutinin-agarose, and DE 52 column chromatography. Rotary shadowed image of dystrophin molecules was dumpbell-shaped dimer, 100-120nm long. There were frequently linear aggregates of the dumpbell dimer.

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