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First direct fluorination of tyrosine-containing biologically active peptides

1990; Elsevier BV; Volume: 31; Issue: 5 Linguagem: Inglês

10.1016/s0040-4039(00)94583-0

1873-3581

D. HEBEL, Kiaran Kirk, Louis A. Cohen, Virender M. Labroo,

Chemical Synthesis and Analysis

Using acetyl hypoflurite a regiospecific electrophilic fluorination of the tyrosine ring of the N-terminal tetrapeptide amide (Tyr-D-Ala-Phe-Gly-NH2) sequence of the opiate peptide dermorphin has been achieved in good yields.