Structure-Based Strategies for Drug Design and Discovery
1992; American Association for the Advancement of Science; Volume: 257; Issue: 5073 Linguagem: Inglês
10.1126/science.257.5073.1078
ISSN1095-9203
Autores Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoMost drugs have been discovered in random screens or by exploiting information about macromolecular receptors. One source of this information is in the structures of critical proteins and nucleic acids. The structure-based approach to design couples this information with specialized computer programs to propose novel enzyme inhibitors and other therapeutic agents. Iterated design cycles have produced compounds now in clinical trials. The combination of molecular structure determination and computation is emerging as an important tool for drug development. These ideas will be applied to acquired immunodeficiency syndrome (AIDS) and bacterial drug resistance.
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