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Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

2014; American Association for the Advancement of Science; Volume: 343; Issue: 6176 Linguagem: Inglês

10.1126/science.1248943

1095-9203

Christoph A. Diebolder, Frank J. Beurskens, Rob N. de Jong, Roman I. Koning, Kristin Strumane, Margaret A. Lindorfer, Marleen Voorhorst, Deniz Ugurlar, Sara Rosati, Albert J. R. Heck, Jan G. J. van de Winkel, Ian A. Wilson, Abraham J. Koster, Ronald P. Taylor, Erica Ollmann Saphire, Dennis R. Burton, Janine Schuurman, Piet Gros, Paul W.H.I. Parren,

Complement system in diseases

Hexing Complement Complement activation is an immediate and potent immune defense mechanism, but how immunoglobulin G (IgG) antibodies activate complement at the molecular level is poorly understood. Using high-resolution crystallography, Diebolder et al. (p. 1260 ) show that human IgGs form hexameric structures by interacting with neighboring IgG molecules, and the complex then activates complement. Thus, IgG molecules and the complement system can coexist in the blood because complement activation will only be triggered after IgG senses a surface antigen and starts to aggregate.