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AGRANULOCYTIC ANGINA

1933; American Medical Association; Volume: 100; Issue: 24 Linguagem: Inglês

10.1001/jama.1933.02740240013003

2376-8118

Francis L. Foran, Howard M. Sheaff, Ralph W. Trimmer,

Cancer Treatment and Pharmacology

The syndrome described by Schultz 1 under the term of agranulocytic angina, and more recently known as malignant neutropenia 2 or pernicious leukopenia, 3 still presents a grave, acute medical emergency for which no highly satisfactory treatment has yet been finally demonstrated. Doan 2 gives the mortality of the untreated cases at 90 plus per cent; of those treated by blood transfusions, at 64 per cent, and of those treated by roentgen irradiation, at 53 per cent. Jackson and his associates 4 report a corrected mortality rate of 30 per cent for the pentose nucleotides, in which deaths during the first seventy-two hours of treatment and cases otherwise inadequately treated are excluded. One of us 5 reported a case in which the treatment of this disease by the intravenous administration of liver extract was followed by recovery. We are now engaged in further study of this therapy and present these