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Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

2007; Lippincott Williams & Wilkins; Volume: 14; Issue: 1 Linguagem: Inglês

10.1002/lt.21351

1527-6473

Vishal Bhagat, Julie Foont, Eugene R. Schiff, Arie Regev,

Liver Disease Diagnosis and Treatment

Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HCV-HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti-HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long-term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV-HCV–coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear. Liver Transpl 14:92–95, 2008. © 2007 AASLD.