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Effects of nicotinic acid therapy on high-density ldpoprotein metabolism in type II and type IV hyperlipoproteinaemia

1980; Elsevier BV; Volume: 618; Issue: 1 Linguagem: Inglês

10.1016/0005-2760(80)90053-3

1879-145X

Christopher J. Packard, Jennifer M. Stewart, Jane L.H.C. Third, Hugh Morgan, T. D. V. Lawrie, James Shepherd,

Diabetes, Cardiovascular Risks, and Lipoproteins

This study investigates the influence of pharmacologie doses of nicotinic acid on HDL metabolism in six type II and four type IV hyperlipoproteinaemic subjects. Although the drug lowered the level of triacylglycerol and VLDL-cholesterol in the type II group, it produced no significant change in the plasma concentrations of LDL-cholesterol, HDL-cholesterol, HDL2, HDL3 and apolipoproteins A-I and A-II. However, separation of the group into IIa and IIb subtypes revealed a marked divergence in their response to treatment. The former exhibited a substantial reduction in plasma triacylglycerol and a striking rise in the HDL2/HDL3 ratio while in the latter these parameters were little affected by the drug. In the type IV subjects nicotinic acid lowered both cholesterol and triacylglycerol levels, the former deriving from a reduction in the level of that lipid associated with VLDL. In contrast, HDL-cholesterol rose significantly in this group, as did both HDL2 and HDL3. These changes were accompanied by an increase in plasma apolipoprotein A-I due to a fall in its fractional rate of catabolism. The plasma apolipoprotein A-II level was unaffected by treatment. These differing responses to nicotinic acid treatment may reflect a differential effect of the drug on triacylglycerol and VLDL metabolism in normoand hypertriglyceridaemic subjects.