Periodic Production of Antiplatelet Autoantibody Directed against GPIIIa in Cyclic Thrombocytopenia
1993; Karger Publishers; Volume: 89; Issue: 3 Linguagem: Inglês
10.1159/000204510
ISSN1421-9662
AutoresMutsumasa Yanabu, Shosaku� Nomura, Tsutomu Fukuroi, Toshihiro Kawakatsu, Hirofumi Kido, Kazuyuki Yamaguchi, Masahiko Suzuki, Terutoshi Kokawa, Kōjirō Yasunaga,
Tópico(s)Blood properties and coagulation
ResumoWe report here a female patient with cyclic thrombocytopenia associated with antiplatelet autoantibodies. There was an inverse relationship between the level of platelet-associated IgG and platelet count. Bone marrow megakaryocytes were normal in number even during the thrombocytopenia. The binding of monoclonal antibodies (mAbs) against glycoprotein (GP) Ilb/IIIa to patient platelets was significantly inhibited in the thrombocytopenic phase, while these mAbs normally bound to patient platelets obtained during the normal platelet count. Western blotting and mAb-specific immobilization of platelet antigens showed that both plasma autoantibody and the eluted IgG from the patient platelets bound to GPIIIa. These results suggest that the periodic production of antiplatelet autoantibody against GPIIIa caused cyclic destruction of platelets in this patient.
Referência(s)