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Near‐Infrared Light‐Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles

2012; Volume: 24; Issue: 21 Linguagem: Inglês

10.1002/adma.201104797

1521-4095

Xinjian Yang, Xia Liu, Zhen Liu, Fang Pu, Jinsong Ren, Xiaogang Qu,

RNA Interference and Gene Delivery

Advanced MaterialsVolume 24, Issue 21 p. 2890-2895 Communication Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles Xinjian Yang, Xinjian Yang Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Search for more papers by this authorXia Liu, Xia Liu Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Search for more papers by this authorZhen Liu, Zhen Liu Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Search for more papers by this authorFang Pu, Fang Pu Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Search for more papers by this authorJinsong Ren, Corresponding Author Jinsong Ren [email protected] Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.Search for more papers by this authorXiaogang Qu, Corresponding Author Xiaogang Qu [email protected] Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.Search for more papers by this author Xinjian Yang, Xinjian Yang Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Search for more papers by this authorXia Liu, Xia Liu Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Search for more papers by this authorZhen Liu, Zhen Liu Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Search for more papers by this authorFang Pu, Fang Pu Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Search for more papers by this authorJinsong Ren, Corresponding Author Jinsong Ren [email protected] Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.Search for more papers by this authorXiaogang Qu, Corresponding Author Xiaogang Qu [email protected] Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.Search for more papers by this author First published: 27 April 2012 https://doi.org/10.1002/adma.201104797Citations: 364Read the full textAboutPDF ToolsRequest 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Learn more.Copy URL Graphical Abstract A novel cell-targeting, near-infrared light-responsive drug delivery platform based on mesoporous silica-coated gold nanorods that are surface-functionalized with aptamer DNA is constructed. Aptamer DNA is used as both capping and targeting agent. In vitro studies show the feasibility of using this nanocarrier for targeted and noninvasive remote controlled drug delivery and photothermal therapy. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description adma_201104797_sm_suppl.pdf476.8 KB suppl Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume24, Issue21June 5, 2012Pages 2890-2895 RelatedInformation