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Mismatch Repair Gene MSH3 Polymorphism is Associated With the Risk of Sporadic Prostate Cancer

2008; Lippincott Williams & Wilkins; Volume: 179; Issue: 5 Linguagem: Inglês

10.1016/j.juro.2008.01.009

1527-3792

Hiroshi Hirata, Yuji Hinoda, Ken Kawamoto, Nobuyuki Kikuno, Yutaka Suehiro, Naoko Okayama, Yuichiro Tanaka, Rajvir Dahiya,

Cancer Genomics and Diagnostics

No AccessJournal of UrologyInvestigative Urology1 May 2008Mismatch Repair Gene MSH3 Polymorphism is Associated With the Risk of Sporadic Prostate Canceris companion ofThe Arachidonic Acid Pathway and its Role in Prostate Cancer Development and ProgressionPrognostic Significance of α-Methylacyl-CoA Racemase Among Men With High Grade Prostatic Intraepithelial Neoplasia in Prostate BiopsiesThe Ratio of Serum Testosterone-to-Prostate Specific Antigen Predicts Prostate Cancer in Hypogonadal MenPCA3 Molecular Urine Assay Correlates With Prostate Cancer Tumor Volume: Implication in Selecting Candidates for Active Surveillance Hiroshi Hirata, Yuji Hinoda, Ken Kawamoto, Nobuyuki Kikuno, Yutaka Suehiro, Naoko Okayama, Yuichiro Tanaka, and Rajvir Dahiya Hiroshi HirataHiroshi Hirata , Yuji HinodaYuji Hinoda , Ken KawamotoKen Kawamoto , Nobuyuki KikunoNobuyuki Kikuno , Yutaka SuehiroYutaka Suehiro , Naoko OkayamaNaoko Okayama , Yuichiro TanakaYuichiro Tanaka , and Rajvir DahiyaRajvir Dahiya View All Author Informationhttps://doi.org/10.1016/j.juro.2008.01.009AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The mismatch repair system is a DNA repair mechanism that corrects mispaired bases during DNA replication errors. Cancer cells deficient in MMR proteins have a 102 to 103-fold increase in the mutation rate. Single nucleotide polymorphisms of mismatch repair genes have been shown to cause a decrease in DNA repair activity. We hypothesized that mismatch repair gene polymorphism could be a risk factor for prostate cancer and p53 Pro/Pro genotype carriers could influence MSH3 and MSH6 polymorphisms. Materials and Methods: DNA samples from 110 patients with prostate cancer and 110 healthy controls were analyzed by single strand conformational polymorphism and polymerase chain reaction-restriction fragment length polymorphism to determine the genotypic frequency of 5 polymorphic loci on 2 MMR genes (MSH3 and MSH6) and p53 codon72. The chi-square test was applied to compare genotype frequency between patients and controls. Results: A significant increase in the G/A+A/A genotype of MSH3 Pro222Pro was observed in patients compared to controls (OR 1.87, 95% CI 1.0–3.5). The frequency of A/G + G/G genotypes of MSH3 exon23 Thr1036Ala also tended to increase in patients (OR 1.57, 95% CI 0.92–2.72). In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05–4.34). Conclusions: To our knowledge this is the first report of the association of MSH3 gene polymorphisms in prostate cancer. These results suggest that the MSH3 polymorphism may be a risk factor for prostate cancer. References 1 : Green tea consumption and prostate cancer risk in Japanese men: a prospective study. Am J Epidemiol2008; 167: 71. Google Scholar 2 : Prevalence, treatment modalities and prognosis of familial prostate cancer in a screened population. J Urol2006; 175: 1332. Link, Google Scholar 3 : Dietary agents in the chemoprevention of prostate cancer. Nutr Cancer2005; 53: 18. Google Scholar 4 : DNA mismatch repair: functions and mechanisms. Chem Rev2006; 106: 302. Google Scholar 5 : Familial endometrial cancer in female carriers of MSH6 germline mutations. Nat Genet1999; 23: 142. Google Scholar 6 : Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Res1997; 57: 3920. Google Scholar 7 : Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat Genet1996; 14: 102. Google Scholar 8 : Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2. Cancer Epidemiol Biomarkers Prev2000; 15: 1636. Google Scholar 9 : Polymorphisms in the hMSH2 gene and the risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev2006; 215: 762. Google Scholar 10 : Common variants in mismatch repair genes and risk of invasive ovarian cancer. Carcinogenesis2006; 27: 2235. Google Scholar 11 : DNA mismatch repair enzyme activity and gene expression in prostate cancer. Biochem Biophys Res Commun2001; 285: 409. Google Scholar 12 : Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol1999; 19: 1092. Google Scholar 13 : Age of diagnosis of colorectal cancer in HNPCC patients is more complex than that predicted by R72P polymorphism in P53. Int J Cancer2006; 118: 2479. Google Scholar 14 : Tissue microarray analysis of hMSH2 expression predicts outcome in men with prostate cancer. J Urol2005; 174: 1814. Link, Google Scholar 15 : Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer. Int J Oncol2003; 22: 1033. Google Scholar 16 : Functional overlap in mismatch repair by human MSH3 and MSH6. Genetics1998; 148: 1637. Google Scholar 17 : Frameshift mutations and a length polymorphism in the hMSH3 gene and the spectrum of microsatellite instability in sporadic colon cancer. Jpn J Cancer Res1999; 90: 1310. Google Scholar 18 : Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability. J Hum Genet2000; 45: 228. Google Scholar 19 : A p53 codon 72 polymorphism associated with prostate cancer development and progression in Japanese. J Biomed Sci2003; 10: 430. Google Scholar 20 : Association of codon 72 polymorphism of p53 with lower prostate cancer risk. Prostate2001; 49: 263. Google Scholar Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California, and Department of Laboratory Medicine, Yamaguchi University Graduate School of Medicine (YH, YS, NO), Yamaguchi, Japan© 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byTaneja S (2018) Re: Treatment Outcomes and Tumor Loss of Heterozygosity in Germline DNA Repair-Deficient Prostate CancerJournal of Urology, VOL. 199, NO. 5, (1113-1113), Online publication date: 1-May-2018.Taneja S (2018) Re: Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate CancerJournal of Urology, VOL. 197, NO. 2, (399-400), Online publication date: 1-Feb-2017.Related articlesJournal of Urology17 Mar 2008The Arachidonic Acid Pathway and its Role in Prostate Cancer Development and ProgressionJournal of Urology17 Mar 2008Prognostic Significance of α-Methylacyl-CoA Racemase Among Men With High Grade Prostatic Intraepithelial Neoplasia in Prostate BiopsiesJournal of Urology17 Mar 2008The Ratio of Serum Testosterone-to-Prostate Specific Antigen Predicts Prostate Cancer in Hypogonadal MenJournal of Urology18 Mar 2008PCA3 Molecular Urine Assay Correlates With Prostate Cancer Tumor Volume: Implication in Selecting Candidates for Active Surveillance Volume 179Issue 5May 2008Page: 2020-2024 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordsprostatic neoplasmsgenesgeneticpolymorphismp53prostateDNA mismatch repair geneAcknowledgmentsDr. Roger Erickson assisted with the manuscript.MetricsAuthor Information Hiroshi Hirata More articles by this author Yuji Hinoda More articles by this author Ken Kawamoto More articles by this author Nobuyuki Kikuno More articles by this author Yutaka Suehiro More articles by this author Naoko Okayama More articles by this author Yuichiro Tanaka More articles by this author Rajvir Dahiya More articles by this author Expand All Advertisement PDF downloadLoading ...