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BIBTEX RIS

Longitudinal clinical and serological survey of abdominal angiostrongyliasis in Guaporé, southern Brazil, from 1995 to 1999

2005; Brazilian Society of Tropical Medicine; Volume: 38; Issue: 4 Linguagem: Inglês

10.1590/s0037-86822005000400006

1678-9849

Carlos Graeff-Teixeira, Aline Hamilton Goulart, Charles de Ornellas Brum, Antônio Carlo Laitano, Charlotte Sievers-Tostes, Graziela Maria Zaniní, Patrícia Leão Bered, Alessandra Loureiro Morassutti, Stefan Michael Geiger, Elizabeth Abrahms-Sandi, Fernanda Teixeira dos Santos Oliveira, Rafael Lucyk Maurer, Luís Felipe Schmidt de Aguiar, Cinara Tentardini Garrido, Ana Cristina Arámburu da Silva, Rubens Rodriguez, H. Schulz‐Key, Aventino Alfredo Agostini,

Parasitic Diseases Research and Treatment

Abdominal angiostrongyliasis is a zoonotic infection caused by Angiostrongylus costaricensis, a nematode with an intra-vascular location in the mesentery. Our objective was to address several aspects of the natural history of this parasitosis, in a longitudinal clinical and seroepidemiological study. A total of 179 individuals living in a rural area with active transmission in southern Brazil were followed for five years (1995-1999) resulting in yearly prevalence of 28.2%, 4.2%, 10%, 20.2% and 2.8% and incidences of 0%, 5.9%, 8% and 1.5%, respectively. Both men and woman were affected with higher frequencies at age 30-49 years. In 32 individuals serum samples were collected at all time points and IgG antibody reactivity detected by ELISA was variable and usually persisting not longer than one year. Some individual antibody patterns were suggestive of re-infection. There was no association with occurrence of abdominal pain or of other enteroparasites and there was no individual with a confirmed (histopathologic) diagnosis. Mollusks were found with infective third-stage larvae in some houses with an overall prevalence of 16% and a low parasitic burden. In conclusion, abdominal angiostrongyliasis in southern Brazil may be a frequent infection with low morbidity and a gradually decreasing serological reactivity.