Produção Nacional
Revisado por pares
Desenvolvimento e validação de método analítico para determinação do teor de sinvastatina em cápsulas magistrais
2011; Brazilian Chemical Society; Volume: 34; Issue: 3 Linguagem: Inglês
10.1590/s0100-40422011000300026
ISSN1678-7064
AutoresHudson Polonini, Felipe Cerqueira dos Santos, Urias Pardócimo Vaz, Marcos Antônio Fernandes Brandão, Nádia Rezende Barbosa Raposo, Anderson de Oliveira Ferreira,
Tópico(s)Public Health in Brazil
ResumoSIMVASTATIN IN CAPSULES.Simvastatin is an oral anti-hyperlipidemic that has been widely used to reduce the cardiovascular disease risk.There isn't any pharmacopoeic method to assay this drug in capsules.It was proposed and validated a method for determining the content of simvastatin in capsules by UV/visible spectrophotometry (λ = 237 nm), a more affordable method for the compounding pharmacy.The method was validated for linearity, specificity, range, accuracy, precision, performance, robustness, and limits of detection and quantification.
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