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Metal-Mediated Deamination of Cytosine: Experiment and DFT Calculations

2004; Wiley; Volume: 43; Issue: 40 Linguagem: Inglês

10.1002/anie.200460107

1521-3773

Judit E. Šponer, Pablo J. Sanz Miguel, Luis Rodríguez‐Santiago, Andrea Erxleben, Michael Krumm, Mariona Sodupe, Jiřı́ Šponer, Bernhard Lippert,

DNA Repair Mechanisms

A mechanism goes platinum: Hydrolytic deamination of cytosine is a major mutagenic event in DNA. Studies with a model system and DFT calculcations demonstrate that deamination is facilitated by coordination of the PtII center to the N3 atom (see scheme; C=cytosine, U=uracil).