CUTANEOUS LESIONS OCCURRING IN THE COURSE OF STREPTOMYCIN THERAPY
1949; American Medical Association; Volume: 60; Issue: 3 Linguagem: Inglês
10.1001/archderm.1949.01530030069007
ISSN1538-3652
Autores Tópico(s)Chemotherapy-related skin toxicity
ResumoDERMATITIS in the course of streptomycin therapy was noted by Heilman and associates in 1945. 1 These authors warned that, though such cutaneous lesions do not call for cessation of treatment with streptomycin, it is important for one to be on the alert for severe dermatitis. In the report on streptomycin by the National Research Council, 2 49 cutaneous eruptions were mentioned. These were erythematous, urticarial, maculopapular or hemorrhagic. Steiner and Fishburn 3 reported 7 cases of rashes occurring during the administration of streptomycin. They stated the belief that these reactions are not toxic but allergic. In their report to the Council on Pharmacy and Chemistry 4 the Study Units of the Veterans Administration, the Army and the Navy stated that in 18 per cent of 223 cases in which 2 Gm. of streptomycin was given daily a pruritic, erythematous, maculopapular skin eruption appeared after about
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