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Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

2014; Elsevier BV; Volume: 125; Issue: 6 Linguagem: Inglês

10.1182/blood-2014-06-585513

1528-0020

Iléana Antony‐Debré, Vladimir T. Manchev, Nathalie Balayn, Dominique Bluteau, Cécile Tomowiak, Céline Legrand, Thierry Langlois, Olivia Bawa, Lucie Tosca, Gérard Tachdjian, Bruno Leheup, Najet Debili, Isabelle Plo, Jason A. Mills, Deborah L. French, Mitchell J. Weiss, Éric Solary, Rémi Favier, William Vainchenker, Hana Raslová,

Blood disorders and treatments

Key Points A half loss of RUNX1 activity leads to defects in primitive erythropoiesis, megakaryopoiesis, and proplatelet formation. An almost complete loss of RUNX1 activity leads to the amplification of the granulomonocytic compartment with increased genomic instability.