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Two New Cytotoxic and Virucidal Trisulfated Triterpene Glycosides from the Antarctic Sea Cucumber Staurocucumis liouvillei

2001; American Chemical Society; Volume: 64; Issue: 6 Linguagem: Inglês

10.1021/np000584i

1520-6025

Marta S. Maier, Alejandro J. Roccatagliata, Anabel Kuriss, Hugo D. Chludil, Alicia M. Seldes, Carlos A. Pujol, Elsa B. Damonte,

Bioactive Compounds and Antitumor Agents

Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 μg/mL.