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The biology and chemistry of high-valent iron–oxo and iron–nitrido complexes

2012; Nature Portfolio; Volume: 3; Issue: 1 Linguagem: Inglês

10.1038/ncomms1718

2041-1723

Johannes Hohenberger, Kallol Ray, Karsten Meyer,

Advanced oxidation water treatment

High-valent iron–oxo and –nitrido complexes are intermediates in the catalytic cycles of various metalloenzymes that activate dioxygen and dinitrogen. Hohenbergeret al. review the advances in the chemistry of model high-valent iron–oxo and –nitrido systems and relate them to our understanding of related enzymes. Selective functionalization of unactivated C–H bonds and ammonia production are extremely important industrial processes. A range of metalloenyzmes achieve these challenging tasks in biology by activating dioxygen and dinitrogen using cheap and abundant transition metals, such as iron, copper and manganese. High-valent iron–oxo and –nitrido complexes act as active intermediates in many of these processes. The generation of well-described model compounds can provide vital insights into the mechanism of such enzymatic reactions. Advances in the chemistry of model high-valent iron–oxo and –nitrido systems can be related to our understanding of the biological systems.