Acidosis protection during 24-hour ischemic heart preservation
1977; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês
10.1016/0011-2240(77)90005-0
ISSN1090-2392
AutoresM Bercot, F Morales, M. De Mendonça, M.J. Appel, Jocelyne Bidault, D. Masson‐Pierre, Bernard Ribalet, D. Paillette,
Tópico(s)Enzyme function and inhibition
ResumoPuppies' hearts were preserved under hypothermic ischemic conditions. They were initially flushed with an intracellular type solution. It was shown that ATP stores were better maintained if the fluid was acid. The level of ATP at the end of 24 hr is compatible with recovery. In these conditions, the study of lactate production and tissue pH seems to indicate that it is due to a slower ATP decrease rate. The pH of the perfusate might act at the extracellular side of the myocardial cell. If hearts were reperfused after such a preservation, they resumed a sinus rhythm and strong contraction after isoproterenol infusion.
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