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Orbital Meningioma with a Granular Cell Component in a Dog, with Extracranial Metastasis

2005; Elsevier BV; Volume: 133; Issue: 2-3 Linguagem: Inglês

10.1016/j.jcpa.2005.02.003

1532-3129

Valentín Pérez Pérez, Enríc Vidal, Natalia Bejarano González, Júlio Benavides, M.C. Ferreras, María Pilar Samper Villagrasa, Martı́ Pumarola,

Soft tissue tumor case studies

A meningioma with a significant component of granular cells is described in the left ocular orbit of a 5-year-old male Golden retriever dog that presented with exophthalmos. The neoplastic mass surrounded the optic nerve. Microscopically, the tumour was characterized by nests of large, round to polygonal cells, variable in size, with eccentric nuclei and abundant eosinophilic cytoplasm, containing PAS-positive granules. In focal areas, cells were smaller and occasionally formed whorl-like structures. Immunohistochemical analysis revealed that neoplastic cells reacted positively for vimentin and, with less intensity, for neuron specific enolase and S-100, whereas they were negative for glial fibrillary acidic protein and cytokeratins. Metastatic growths, formed by similar cells, were seen in the lung and heart.