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A Clinical Planning Module for Adaptive Optics SLO Imaging

2012; Lippincott Williams & Wilkins; Volume: 89; Issue: 5 Linguagem: Inglês

10.1097/opx.0b013e318253e081

1538-9235

Gang Huang, Xiaofeng Qi, Toco Yuen Ping Chui, Zhangyi Zhong, Stephen A. Burns,

Ophthalmology and Visual Impairment Studies

Purpose. To develop a clinical planning module (CPM) to improve the efficiency of imaging subjects with a steerable wide-field adaptive optics scanning laser ophthalmoscope (AOSLO) and to evaluate the performance of this module by imaging the retina in healthy and diseased eyes. Methods. We developed a software-based CPM with two submodules: a navigation module and a montage acquisition module. The navigation module guides the AOSLO to image identified retinal regions from a clinical imaging platform using a matrix-based mapping between the two. The montage acquisition module systematically moves the AOSLO steering mirrors across the retina in predefined patterns. The CPM was calibrated using a model eye and tested on five normal subjects and one patient with a retinal nerve fiber layer defect. Results. Within the central ±7° from the fixation target, the CPM can direct the AOSLO beam to the desired regions with localization errors of 0.05). The region with a size of approximately 13° × 10° can be imaged in about 30 min. An approximately 12° × 4.5° montage of the diseased region from a patient was imaged in 18 min. Conclusions. We have implemented a clinical planning module to accurately guide the AOSLO imaging beam to desired locations and to quickly acquire high-resolution AOSLO montages. The approach is not only friendly for patients and clinicians but also convenient to relate the imaging data between different imaging platforms.