The Role of Troponins in Muscle Contraction
2002; Wiley; Volume: 54; Issue: 6 Linguagem: Inglês
10.1080/15216540216037
ISSN1521-6551
AutoresAldrin V. Gomes, James D. Potter, Danuta Szczesna‐Cordary,
Tópico(s)Muscle Physiology and Disorders
ResumoAbstract Troponin (Tn) is the sarcomeric Ca 2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca 2+ Tn transmits information via structural changes throughout the actin‐tropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn‐mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.
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