Portal de Periódicos da CAPES

Aluminum-Catalyzed Asymmetric Addition of TMSCN to Aromatic and Aliphatic Ketones Promoted by an Easily Accessible and Recyclable Peptide Ligand

2002; Wiley; Volume: 41; Issue: 6 Linguagem: Inglês

10.1002/1521-3773(20020315)41

1521-3773

Hongbo Deng, Markus P. Isler, Marc L. Snapper, Amir H. Hoveyda,

Asymmetric Synthesis and Catalysis

Angewandte Chemie International EditionVolume 41, Issue 6 p. 1009-1012 Communication Aluminum-Catalyzed Asymmetric Addition of TMSCN to Aromatic and Aliphatic Ketones Promoted by an Easily Accessible and Recyclable Peptide Ligand Hongbo Deng Dr., Hongbo Deng Dr. Department of Chemistry, Merkert Chemistry Center Boston College Chestnut Hill, MA 02467, USA, Fax: (+1) 617-552-1442Search for more papers by this authorMarkus P. Isler Dr., Markus P. Isler Dr. Department of Chemistry, Merkert Chemistry Center Boston College Chestnut Hill, MA 02467, USA, Fax: (+1) 617-552-1442Search for more papers by this authorMarc L. Snapper Prof., Marc L. Snapper Prof. marc.snapper@bc.edu Department of Chemistry, Merkert Chemistry Center Boston College Chestnut Hill, MA 02467, USA, Fax: (+1) 617-552-1442Search for more papers by this authorAmir H. Hoveyda Prof., Amir H. Hoveyda Prof. amir.hoveyda@bc.edu Department of Chemistry, Merkert Chemistry Center Boston College Chestnut Hill, MA 02467, USA, Fax: (+1) 617-552-1442Search for more papers by this author Hongbo Deng Dr., Hongbo Deng Dr. Department of Chemistry, Merkert Chemistry Center Boston College Chestnut Hill, MA 02467, USA, Fax: (+1) 617-552-1442Search for more papers by this authorMarkus P. Isler Dr., Markus P. Isler Dr. Department of Chemistry, Merkert Chemistry Center Boston College Chestnut Hill, MA 02467, USA, Fax: (+1) 617-552-1442Search for more papers by this authorMarc L. Snapper Prof., Marc L. Snapper Prof. marc.snapper@bc.edu Department of Chemistry, Merkert Chemistry Center Boston College Chestnut Hill, MA 02467, USA, Fax: (+1) 617-552-1442Search for more papers by this authorAmir H. Hoveyda Prof., Amir H. Hoveyda Prof. amir.hoveyda@bc.edu Department of Chemistry, Merkert Chemistry Center Boston College Chestnut Hill, MA 02467, USA, Fax: (+1) 617-552-1442Search for more papers by this author First published: 15 March 2002 https://doi.org/10.1002/1521-3773(20020315)41:6 3.0.CO;2-FCitations: 132 This research was supported by the United States National Institutes of Health (GM-57212), Novartis, and the Swiss National Science Foundation (postdoctoral fellowships to M.P.I.). TMSCN=trimethylsilyl cyanide. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Easily prepared peptide-based ligands efficiently promote the Al-catalyzed enantioselective addition of trimethylsilyl cyanide (TMSCN) to aromatic, aliphatic, cyclic, and acyclic ketones (see scheme for an example). The chiral ligands can be readily recovered and reused without loss of activity or selectivity. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z18148_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume41, Issue6March 15, 2002Pages 1009-1012 RelatedInformation