Hereditary Prostate Cancer: Clinical Characteristics and Survival
2002; Lippincott Williams & Wilkins; Volume: 167; Issue: 6 Linguagem: Inglês
10.1016/s0022-5347(05)64997-x
ISSN1527-3792
AutoresOla Bratt, J.‐E. Damber, Monica Emanuelsson, Henrik Grönberg,
Tópico(s)Prostate Cancer Diagnosis and Treatment
ResumoNo AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jun 2002Hereditary Prostate Cancer: Clinical Characteristics and Survival O. BRATT, J.-E. DAMBER, M. EMANUELSSON, and H. GRÖNBERG O. BRATTO. BRATT , J.-E. DAMBERJ.-E. DAMBER , M. EMANUELSSONM. EMANUELSSON , and H. GRÖNBERGH. GRÖNBERG View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64997-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Hereditary prostate cancer accounts for 5% to 10% of all prostate cancer cases. We assessed clinical characteristics and survival in patients with hereditary prostate cancer Materials and Methods: The study comprised 201 patients from 62 Swedish hereditary prostate cancer families and 402 controls with prostate cancer who were matched for age and calendar year at diagnosis, and the hospital where the diagnosis was made. Clinical data were obtained from the National Cancer Registry, Causes of Death Registry and medical records. Results: Median age at the diagnosis of hereditary prostate cancer was 68 years, which was 6 years less than in patients with prostate cancer in the general population in Sweden. Distributions of tumor grade, symptoms at diagnosis and initial therapy were similar in hereditary prostate cancer cases and controls. More controls were classified with localized disease but it may have been due to methodological problems. Overall and cancer specific survival was similar in patients with hereditary prostate cancer and controls as well as in subgroup analyses including those with early onset and those diagnosed before 1990. Prostate cancer was the cause of death in 75% of patients with hereditary prostate cancer, in contrast to 55% with prostate cancer in the Swedish population. This difference was completely explained by the earlier age at the diagnosis of hereditary prostate cancer. Conclusions: Hereditary prostate cancer has an earlier onset than sporadic prostate cancer but this study did not indicate any other important difference in clinical characteristics or survival in patients with hereditary prostate cancer and those with sporadic prostate cancer. However, it cannot be excluded that individual hereditary prostate cancer genes may have specific biological characteristics. References 1 : Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science1996; 274: 1371. Google Scholar 2 : Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2–43. Am J Hum Genet1998; 62: 1416. Google Scholar 3 : Evidence for a prostate cancer susceptibility locus on the X chromosome (letter to the editor). Nat Genet1998; 20: 175. Google Scholar 4 : Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet1999; 64: 776. 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Google Scholar From the Unit for Urology, Helsingborg Hospital, Department of Urology, Sahlgrenska University Hospital, Gothenburg and Department of Oncology, Umeå University Hospital, Umeå, Sweden© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byRoemeling S, Roobol M, de Vries S, Gosselaar C, van der Kwast T and Schröder F (2018) Prevalence, Treatment Modalities and Prognosis of Familial Prostate Cancer in a Screened PopulationJournal of Urology, VOL. 175, NO. 4, (1332-1336), Online publication date: 1-Apr-2006.Roehl K, Loeb S, Antenor J, Corbin N and Catalona W (2018) Characteristics of Patients With Familial Versus Sporadic Prostate CancerJournal of Urology, VOL. 176, NO. 6, (2438-2442), Online publication date: 1-Dec-2006.Bratt O (2018) Hereditary Prostate Cancer: Clinical AspectsJournal of Urology, VOL. 168, NO. 3, (906-913), Online publication date: 1-Sep-2002. Volume 167Issue 6June 2002Page: 2423-2426 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordsprostatic neoplasmsgenetic diseases, inborngene expressionprostatesurvivalMetricsAuthor Information O. BRATT More articles by this author J.-E. DAMBER More articles by this author M. EMANUELSSON More articles by this author H. GRÖNBERG More articles by this author Expand All Advertisement PDF downloadLoading ...
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