Portal de Periódicos da CAPES

Is There A Role for Neurotrophin Treatment of the Ocular Surface Following Laser In Situ Keratomileusis (LASIK)?

2005; Elsevier BV; Volume: 139; Issue: 6 Linguagem: Inglês

10.1016/j.ajo.2005.03.064

1879-1891

Jay S. Pepose, Eugene M. Johnson,

Corneal surgery and disorders

In this issue of the journal, Kim and associates 1 Lee H.K. Lee K.S. Kim H.C. Lee S.H. Kim E.K. Nerve growth factor concentration and implications in photorefractive keratectomy vs laser in situ keratomileusis. Am J Ophthalmol. 2005; 139: 965-971 Abstract Full Text Full Text PDF PubMed Scopus (91) Google Scholar report on nerve growth factor (NGF) in tears after (LASIK). Tear dysfunction may, arguably, represent the most common unwanted sequela of excimer laser vision correction. 2 Albietz J.M. Lenton L.M. Management of the ocular surface and tear film before, during and after laser in situ keratomileusis. J Refract Surg. 2004; 20: 62-71 PubMed Google Scholar Following LASIK, dry eye symptoms, such as dryness and foreign body sensation, are frequent. Studies show an increase in prevalence of dry eye symptoms from 38% preoperatively to 69% to 85% during the first few weeks post-LASIK. 2 Albietz J.M. Lenton L.M. Management of the ocular surface and tear film before, during and after laser in situ keratomileusis. J Refract Surg. 2004; 20: 62-71 PubMed Google Scholar , 3 Toda I. Kato-Asano N. Husi-Kumai Y. Tsubota K. Dry eye after laser in situ keratomileusis. Am J Ophthalmol. 2001; 132: 1-7 Abstract Full Text Full Text PDF PubMed Scopus (220) Google Scholar Ocular irritation scores can remain elevated for up to 12 to 16 months. 3 Toda I. Kato-Asano N. Husi-Kumai Y. Tsubota K. Dry eye after laser in situ keratomileusis. Am J Ophthalmol. 2001; 132: 1-7 Abstract Full Text Full Text PDF PubMed Scopus (220) Google Scholar , 4 Battat L. Macri A. Dursun D. Pflugfelder S.C. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology. 2001; 108: 1230-1235 Abstract Full Text Full Text PDF PubMed Scopus (234) Google Scholar In contrast, studies indicate that non-flap associated forms of excimer laser surface ablation, such as, photorefractive keratectomy (PRK) or laser-assisted sub-epithelial keratectomy (LASEK), may elicit less dry eye symptoms, tear film instability, corneal barrier dysfunction, and corneal hypesthesia compared with LASIK for an equivalent laser ablation depth. 5 Matsui H. Kumano Y. Zushi I. Yamada T. Matsui T. Nishida T. Corneal sensation after correction of myopia by photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg. 2001; 27: 370-373 Abstract Full Text Full Text PDF PubMed Scopus (74) Google Scholar , 6 Perez-Santonja J. Sakla H.F. Cardona C. Chipont E. Alió J.L. Corneal sensitivity after photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg. 2001; 27: 370-373 Abstract Full Text Full Text PDF Google Scholar Jay S. Pepose, MD, PhD, Professor of Clinical Ophthalmology, Washington University School of Medicine, St. Louis, Missouri and Medical Director, Pepose Vision Institute, is a recipient of the Cogan Award from the Association of Research in Vision and Ophthalmology and Senior Honor Award from the American Academy of Ophthalmology. A clinician-investigator with interests in cornea and refractive surgery, Dr. Pepose serves as an Executive Editor of the American Journal of Ophthalmology and the Journal of Refractive Surgery Eugene Johnson, PhD, received his BS in Pharmacy and PhD in Medicinal Chemistry from the University of Maryland and received Postdoctoral Training in Pharmacology from Washington University. He is the Associate Director of the Alzheimer’s Disease Research Center, and serves on the Medical and Scientific Council of the Alzheimer’s Association and the Advisory Council of the National Institute on Aging. He also serves on the Editorial Boards of Neuron and Neurobiology of Disease, and as Section Editor for Experimental Neurology and Neurobiology of Aging