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THE METABOLISM OF THALIDOMIDE: SOME BIOLOGICAL EFFECTS OF THALIDOMIDE AND ITS METABOLITES

1965; Wiley; Volume: 25; Issue: 2 Linguagem: Inglês

10.1111/j.1476-5381.1965.tb02055.x

2056-8177

Sergio Fabro, Herbert Schumacher, Robert L. Smith, R. B. L. STAGG, R. T. Williams,

Cancer therapeutics and mechanisms

British Journal of Pharmacology and ChemotherapyVolume 25, Issue 2 p. 352-362 Free Access THE METABOLISM OF THALIDOMIDE: SOME BIOLOGICAL EFFECTS OF THALIDOMIDE AND ITS METABOLITES S. FABRO, S. FABRO Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorH. SCHUMACHER, H. SCHUMACHER Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. L. SMITH, R. L. SMITH Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. B. L. STAGG, R. B. L. STAGG Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. T. WILLIAMS, R. T. WILLIAMS Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this author S. FABRO, S. FABRO Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorH. SCHUMACHER, H. SCHUMACHER Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. L. SMITH, R. L. SMITH Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. B. L. STAGG, R. B. L. STAGG Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. T. WILLIAMS, R. T. WILLIAMS Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this author First published: October 1965 https://doi.org/10.1111/j.1476-5381.1965.tb02055.xCitations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES Baxter, C. F. & Roberts, E. (1960). Gamma-aminobutyric acid and cerebral metabolism. In The Neurochemistry of Nucleotides and Amino Acids, ed. R. O. Brady & D. B. Tower, p. 127. London: J. Wiley & Sons. Caughey, W. S., Smiley, J. D. & Hellerman, L. (1957). l-Glutamic dehydrogenase: structural requirements for substrate competition: effect of thyroxine. J. biol. Chem., 224, 591– 607. Deuchar, E. M. (1962). The roles of amino acids in animal embryogenesis. Biol. Rev., 37, 378– 421. Elliott, W. H. (1951). Studies on the enzymic synthesis of glutamine. Biochem. J., 49, 106– 112. Fabro, S., Schumacher, H., Smith, R. L. & Williams, R. T. (1964). Identification of thalidomide in rabbit blastocysts. Nature (Lond.), 201, 1125– 1126. Felisati, D. (1962). Thalidomide and congenital abnormalities. Lancet, ii, 724– 725. Felisati, D. & Nodari, R. (1963). Effets toxiques et teratogeniques de la thalidomide sur le foetus de lapin. Schweiz. med. Wschr., 93, 1559– 1562. Kalckar, H. M. (1947). Differential spectrophotometry of purine compounds by means of specific enzymes. III. Studies of the enzymes of purine metabolism. J. biol. Chem., 167, 461– 475. Kemper, F. (1962). Thalidomide and congenital abnormalities. Lancet, ii, 836. Meister, A. (1956). Metabolism of glutamine. Physiol. Rev., 36, 103– 127. Murphy, M. L. (1960). Teratogenic effects of tumour-inhibiting chemicals in the foetal rat. In Congenital Malformations, ed. G. E. W. Wolstenholme & M. O'Connor, p. 78. London: Churchill. Rudnick, D., Mele, P. & Waelsch, H. (1955). Development of glutamotransferase and glutamine synthetase in the nervous system of the chick. J. exp. Zool., 129, 309– 341. Schumacher, H., Smith, R. L. & Williams, R. T. (1965). The metabolism of thalidomide: the fate of thalidomide and some of its hydrolysis products in various species. Brit. J. Pharmacol., 25, 338– 351. Smith, R. L., Williams, R. A. D. & Williams, R. T. (1962). Phthaloyhsoglutarnine, a metabolite of thalidomide. Life Sciences, 7, 333– 336. Somers, G. F. (1960). Pharmacological properties of thalidomide (α-phthalimidoglutarimide), a new sedative hypnotic drug. Brit. J. Pharmacol., 15, 111– 116. Somers, G. F. (1962). Thalidomide and congenital abnormalities. Lancet, i, 912– 913. Somers, G. F. (1963). The foetal toxicity of thalidomide. Proc. European Soc. Study Drug Toxicity, 1, 49. Tower, D. B. (1960). The neurochemistry of asparagine and glutamine. In The Neurochemistry of Nucleotides and Amino Acids, ed. R. O. Brady & D. B. Tower, pp. 173– 204. London: J. Wiley & Sons. Citing Literature Volume25, Issue2October 1965Pages 352-362 ReferencesRelatedInformation