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The synthesis of oligodeoxynucleotides containing 2-thiothymine and 5-methyl-4-pyrimidinone base analogues

1992; Elsevier BV; Volume: 33; Issue: 41 Linguagem: Inglês

10.1016/s0040-4039(00)60011-4

1873-3581

Sharanabasava B. Rajur, Larry W. McLaughlin,

Genomics and Chromatin Dynamics

A procedure is described for the Preparation of two thymidine analogues in which the O2-carbonyl is deleted (dH2T) or converted to an O2-thione (ds2T). The phosphoramidites of these nucleosides have been synthesized and used to incorporate the analogues site-specifically into oligodeoxynucleotide sequences.