G2677T and C3435T Genotype and Haplotype Are Associated With Hepatic ABCB1 ( MDR1 ) Expression
2006; Wiley; Volume: 46; Issue: 3 Linguagem: Inglês
10.1177/0091270005284387
ISSN1552-4604
AutoresPengfei Song, Jatinder K. Lamba, Lijun Zhang, Erin G. Schuetz, Nikhil Shukla, Bernd Meibohm, Charles R. Yates,
Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoThe Journal of Clinical PharmacologyVolume 46, Issue 3 p. 373-379 G2677T and C3435T Genotype and Haplotype Are Associated With Hepatic ABCB1 (MDR1) Expression Dr Pengfei Song PhD, Dr Pengfei Song PhD The Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, MemphisSearch for more papers by this authorDr Jatinder K. Lamba PhD, Dr Jatinder K. Lamba PhD The Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TennesseeSearch for more papers by this authorDr Lijun Zhang, Dr Lijun Zhang The Department of Mathematics, University of Memphis, Memphis, TennesseeSearch for more papers by this authorDr Erin Schuetz PhD, Dr Erin Schuetz PhD The Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TennesseeSearch for more papers by this authorMr Nikhil Shukla, Mr Nikhil Shukla The Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, MemphisSearch for more papers by this authorDr Bernd Meibohm PhD, FCP, Dr Bernd Meibohm PhD, FCP The Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, MemphisSearch for more papers by this authorDr Charles R. Yates PharmD, PhD, Corresponding Author Dr Charles R. Yates PharmD, PhD The Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, MemphisAddress for reprints: Charles R. Yates, PharmD, PhD, University of Tennessee College of Pharmacy, 874 Union Avenue Crowe 5 P, Memphis, TN 38163.Search for more papers by this author Dr Pengfei Song PhD, Dr Pengfei Song PhD The Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, MemphisSearch for more papers by this authorDr Jatinder K. Lamba PhD, Dr Jatinder K. Lamba PhD The Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TennesseeSearch for more papers by this authorDr Lijun Zhang, Dr Lijun Zhang The Department of Mathematics, University of Memphis, Memphis, TennesseeSearch for more papers by this authorDr Erin Schuetz PhD, Dr Erin Schuetz PhD The Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TennesseeSearch for more papers by this authorMr Nikhil Shukla, Mr Nikhil Shukla The Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, MemphisSearch for more papers by this authorDr Bernd Meibohm PhD, FCP, Dr Bernd Meibohm PhD, FCP The Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, MemphisSearch for more papers by this authorDr Charles R. Yates PharmD, PhD, Corresponding Author Dr Charles R. Yates PharmD, PhD The Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, MemphisAddress for reprints: Charles R. Yates, PharmD, PhD, University of Tennessee College of Pharmacy, 874 Union Avenue Crowe 5 P, Memphis, TN 38163.Search for more papers by this author First published: 08 March 2013 https://doi.org/10.1177/0091270005284387Citations: 42Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Higgins CF. ABC transporters: from microorganisms to man. Annu Rev Cell Biol. 1992; 8: 61–113. 2 Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci U S A. 1987; 84: 7731–7738. 3 Yumoto R, Murakami T, Nakamoto Y, Hasegawa R, Nagai J, Takano M. Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds. J Pharmacol Exp Ther. 1999; 289: 141–155. 4 Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J Histochem Cytochem. 1989; 37: 151–164. 5 Wijnholds J, de Lange EC, Scheffer GL, et al. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest. 2000; 105: 271–285. 6 Rao US, Fine RL, Scarborough GA. Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994; 48: 281–292. 7 Fromm MF. Importance of P-glycoprotein at blood-tissue barriers. Trends Pharmacol Sci. 2004; 25: 421–429. 8 Lan LB, Dalton JT, Schuetz EG. Mdr1 limits CYP3A metabolism in vivo. Mol Pharmacol. 2000; 58: 861–869. 9 Wu CY, Benet LZ. Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Drug Metab Dispos. 2003; 31: 1291–1295. 10 Chiou WL, Chung SM, Wu TC. Apparent lack of effect of P-glycoprotein on the gastrointestinal absorption of a substrate, tacrolimus, in normal mice. Pharm Res. 2000; 17: 201–208. 11 Smit JW, Schinkel AH, Weert B, Meijer DK. Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted. Br J Pharmacol. 1998; 124: 411–424. 12 Smit JW, Duin E, Steen H, Oosting R, Roggeveld J, Meijer DK. Interactions between P-glycoprotein substrates and other cationic drugs at the hepatic excretory level. Br J Pharmacol. 1998; 123: 361–370. 13 Stapf V, Thalhammer T, Huber-Huber R, Felberbauer F, Gajdzik L, Graf J. Inhibition of rhodamine 123 secretion by cyclosporin A as a model of P-glycoprotein mediated transport in liver. Anticancer Res. 1994; 14: 581–585. 14 Lum BL, Kaubisch S, Yahanda AM, et al. Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance. J Clin Oncol. 1992; 10: 1631–1642. 15 Kivisto KT, Kroemer HK, Eichelbaum M. The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions. Br J Clin Pharmacol. 1995; 40: 521–530. 16 Lamba JK, Lin YS, Thummel K, et al. Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics. 2002; 12: 121–132. 17 Pauli-Magnus C, Kroetz DL. Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1). Pharm Res. 2004; 21: 901–913. 18 Johne A, Kopke K, Gerloff T, et al. Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene. Clin Pharmacol Ther. 2002; 72: 581–594. 19 Mwenifumbo JC, Myers MG, Wall TL, Lin SK, Sellers EM, Tyndale RF. Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method. Pharmacogenet Genomics. 2005; 15: 181–192. 20 Liu W, Saint DA. A new quantitative method of real time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics. Anal Biochem. 2002; 302: 51–59. 21 Liu W, Saint DA. Validation of a quantitative method for real time PCR kinetics. Biochem Biophys Res Commun. 2002; 294: 341–353. 22 Tang K, Wong LP, Lee EJ, Chong SS, Lee CG. Genomic evidence for recent positive selection at the human MDR1 gene locus. Hum Mol Genet. 2004; 13: 781–797. 23 Kim RB, Leake BF, Choo EF, et al. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther. 2001; 70: 181–199. 24 Tang K, Ngoi SM, Gwee PC, et al. Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations. Pharmacogenetics. 2002; 12: 431–450. 25 Kroetz DL, Pauli-Magnus C, Hodges LM, et al. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics. 2003; 13: 481–494. 26 Siegmund W, Ludwig K, Engel G, et al. Variability of intestinal expression of P-glycoprotein in healthy volunteers as described by absorption of talinolol from four bioequivalent tablets. J Pharm Sci. 2003; 92: 601–610. 27 Siegmund W, Ludwig K, Giessmann T, et al. The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol. Clin Pharmacol Ther. 2002; 72: 571–583. 28 Illmer T, Schuler US, Thiede C, et al. MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients. Cancer Res. 2002; 62: 4951–4962. 29 Zheng H, Webber S, Zeevi A, et al. The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients. Hum Immunol. 2002; 63: 761–770. 30 Hoffmeyer S, Burk O, von Richter O, et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A. 2000; 97: 3471–3478. 31 Hitzl M, Schaeffeler E, Hocher B, et al. Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1). Pharmacogenetics. 2004; 14: 301–318. 32 Wang D, Johnson AD, Papp AC, Kroetz DL, Sadee W. Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435CT affects mRNA stability. Pharmacogenet Genomics. 2005; 15: 691–704. 33 Owen A, Goldring C, Morgan P, Chadwick D, Park BK, Pirmohamed M. Relationship between the CT and GT(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver. Br J Clin Pharmacol. 2005; 59: 361–370. 34 Meissner K, Jedlitschky G, Meyer zu Schwabedissen H, et al. Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms. Pharmacogenetics. 2004; 14: 381–385. 35 Oselin K, Nowakowski-Gashaw I, Mrozikiewicz PM, Wolbergs D, Pahkla R, Roots I. Quantitative determination of MDR1 mRNA expression in peripheral blood lymphocytes: a possible role of genetic polymorphisms in the MDR1 gene. Eur J Clin Invest. 2003; 33: 261–267. 36 Goto M, Masuda S, Saito H, et al. C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation. Pharmacogenetics. 2002; 12: 451–457. 37 Lepper ER, Nooter K, Verweij J, Acharya MR, Figg WD, Sparreboom A. Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2. Pharmacogenomics. 2005; 6: 111–138. Citing Literature Volume46, Issue3March 2006Pages 373-379 ReferencesRelatedInformation
Referência(s)