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2177 PHOTOSELECTIVEVAPORIZATION OF THE PROSTATE WITH GREENLIGHT 120W LASER COMPARED TO MONOPOLAR TRANSURETHRAL RESECTION OF THE PROSTATE: A MULTICENTER, RANDOMIZED CONTROLLED TRIAL

2012; Lippincott Williams & Wilkins; Volume: 187; Issue: 4S Linguagem: Inglês

10.1016/j.juro.2012.02.2350

1527-3792

B. Lukacs, Joyce Loeffler, F. Bruyère, Pascal Blanchet, Albert Gelet, P. Coloby, Alexandre de la Taille, Philippe Lemaire, J. H. Baron, Jean‐Nicolas Cornu, Mounir Aout, Hélène Rousseau, Éric Vicaut,

Urinary Bladder and Prostate Research

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Surgical Therapy and New Technology III1 Apr 20122177 PHOTOSELECTIVEVAPORIZATION OF THE PROSTATE WITH GREENLIGHT 120W LASER COMPARED TO MONOPOLAR TRANSURETHRAL RESECTION OF THE PROSTATE: A MULTICENTER, RANDOMIZED CONTROLLED TRIAL Bertrand Lukacs, Joyce Loeffler, Franck Bruyère, Pascal Blanchet, Albert Gelet, Patrick Coloby, Alexandre De la Taille, Philippe Lemaire, Jean-Christophe Baron, Jean-Nicolas Cornu, Mounir Aout, Hélène Rousseau, and Eric Vicaut Bertrand LukacsBertrand Lukacs Paris, France More articles by this author , Joyce LoefflerJoyce Loeffler Nice, France More articles by this author , Franck BruyèreFranck Bruyère Tours, France More articles by this author , Pascal BlanchetPascal Blanchet West French Indies, France More articles by this author , Albert GeletAlbert Gelet Lyon, France More articles by this author , Patrick ColobyPatrick Coloby Pontoise, France More articles by this author , Alexandre De la TailleAlexandre De la Taille Creteil, France More articles by this author , Philippe LemairePhilippe Lemaire Reims, France More articles by this author , Jean-Christophe BaronJean-Christophe Baron Saint Cyr Sur Loire, France More articles by this author , Jean-Nicolas CornuJean-Nicolas Cornu Paris, France More articles by this author , Mounir AoutMounir Aout Paris, France More articles by this author , Hélène RousseauHélène Rousseau Paris, France More articles by this author , and Eric VicautEric Vicaut Paris, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2350AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Evidence supporting the use of Greenlight HPS-120W photovaporization of the prostate (PVP) as an alternative to transurethral resection of the prostate (TURP) in current clinical practice is lacking.Our objective was to assess the non-inferiority of PVP compared to TURP in surgical management of low urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH) and the superiority of PVP over TURP on hospital stay duration. METHODS A multicenter prospective randomized controlled trial was conducted in nine tertiary reference centres. Patients over 50 presenting LUTS/BPH needing surgical relief of prostatic obstruction underwent monopolar TURP or PVP with Greenlight™ HPS-120W laser. Protocol was reviewed by ethics commitee and all patient gave written informed consent to be included in the study. Pre-operative evaluation included International Prostatic Symptom Score (I-PSS), bother (I-PSS question 8), Euro-QOL (quality of life) questionnaire, uroflowmetry, Danish Prostate Symptom Score Sexual (DAN-PSSsex) and overall sexual satisfaction. These items added to peri-operative parameters and adverse events were prospectively collected at 1, 3, 6 and 12 months. The main outcome measure was the I-PSS score at 12 months visit associated with hospital stay duration, compared using the student t test.All analysis was driven according to the intent to treat (ITT) principle. RESULTS 136 patients (68 men in each group) were included in the intent to treat analysis. Median [interquartile range] I-PSS scores at 12 months follow-up were not significantly different between the two groups (5[3-9] for TURP vs 6[3-9] for PVP). Mean length of stay was significantly shorter in the PVP group than in the TURP group (mean±SD (95% confidence interval) 1.78±1.29 [1.52-2.04] vs 3.01±1.63 [2,68-3,34], respectively, p<0.0001). Uroflowmetry parameters, early and late complications, were comparable in both groups at last follow-up. Sexual outcomes, notably ejaculation, were slightly better in the PVP group without reaching statistical significance. CONCLUSIONS PVP is an acceptable alternative to TURP with similar results on LUTS improvement in the short-term. PVP is associated to a reduced hospital stay. A trend towards improvement of sexual parameters, notably ejaculation, has been observed in the PVP group at last follow-up. Longer follow-up studies are required to confirm the clinical benefits of this technique for surgical management of LUTS/BPH. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e878 Peer Review Report Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Bertrand Lukacs Paris, France More articles by this author Joyce Loeffler Nice, France More articles by this author Franck Bruyère Tours, France More articles by this author Pascal Blanchet West French Indies, France More articles by this author Albert Gelet Lyon, France More articles by this author Patrick Coloby Pontoise, France More articles by this author Alexandre De la Taille Creteil, France More articles by this author Philippe Lemaire Reims, France More articles by this author Jean-Christophe Baron Saint Cyr Sur Loire, France More articles by this author Jean-Nicolas Cornu Paris, France More articles by this author Mounir Aout Paris, France More articles by this author Hélène Rousseau Paris, France More articles by this author Eric Vicaut Paris, France More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...