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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Epidermal Growth Factor-induced Vacuolar (H+)-ATPase Assembly

2012; Elsevier BV; Volume: 287; Issue: 31 Linguagem: Inglês

10.1074/jbc.m112.352229

ISSN

1083-351X

Autores

Yanqing Xu, Amanda Parmar, Emmanuelle Roux, Alejandro Balbis, Víctor Dumas, Stéphanie Chevalier, Barry I. Posner,

Tópico(s)

Ubiquitin and proteasome pathways

Resumo

Background: EGF-induced activation of mTORC1 in hepatocytes is essential for cell proliferation.Results: Blocking EGF-induced vacuolar acidification reduced intracellular essential amino acid levels and inhibited mTORC1 signaling without affecting Akt/Erk activation.Conclusion: EGF-induced mTORC1 signaling depends on sustaining intracellular amino acid levels.Significance: Our results support a role for vacuolar acidification in growth factor signaling. Background: EGF-induced activation of mTORC1 in hepatocytes is essential for cell proliferation. Results: Blocking EGF-induced vacuolar acidification reduced intracellular essential amino acid levels and inhibited mTORC1 signaling without affecting Akt/Erk activation. Conclusion: EGF-induced mTORC1 signaling depends on sustaining intracellular amino acid levels. Significance: Our results support a role for vacuolar acidification in growth factor signaling.

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