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Hyaluronic Acid and HYAL-1 in Prostate Biopsy Specimens: Predictors of Biochemical Recurrence

2009; Lippincott Williams & Wilkins; Volume: 182; Issue: 4 Linguagem: Inglês

10.1016/j.juro.2009.06.070

1527-3792

Christopher Gomez, Pablo Gómez, Judith Knapp, Mercè Jordà, Mark S. Soloway, Vinata B. Lokeshwar,

Prostate Cancer Treatment and Research

No AccessJournal of UrologyAdult Urology1 Oct 2009Hyaluronic Acid and HYAL-1 in Prostate Biopsy Specimens: Predictors of Biochemical Recurrenceis accompanied byPeriprostatic Adipose Tissue as a Modulator of Prostate Cancer AggressivenessSemaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis Christopher S. Gomez, Pablo Gomez, Judith Knapp, Merce Jorda, Mark S. Soloway, and Vinata B. Lokeshwar Christopher S. GomezChristopher S. Gomez Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Equal study contribution. More articles by this author , Pablo GomezPablo Gomez Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Equal study contribution. More articles by this author , Judith KnappJudith Knapp Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Department of Urology, Eberhard-Karls-University, Tübingen, Germany More articles by this author , Merce JordaMerce Jorda Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida More articles by this author , Mark S. SolowayMark S. Soloway Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida More articles by this author , and Vinata B. LokeshwarVinata B. Lokeshwar Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, Florida More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.06.070AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Molecular markers could aid prostate specific antigen, biopsy Gleason sum and clinical stage to provide accurate information on prostate cancer progression. HYAL-1 hyaluronidase and hyaluronic acid staining in prostatectomy specimens predicts biochemical recurrence. We examined whether hyaluronic acid and HYAL-1 staining in biopsy specimens predicts biochemical recurrence and correlates with staining in matched prostatectomy specimens. Materials and Methods: Biopsy and prostatectomy specimens were obtained from 61 patients with clinically localized prostate cancer from multiple centers, including 23 with (group 1) and 38 without (group 2) biochemical recurrence. Mean followup was 103.1 months. Biotinylated hyaluronic acid binding protein and anti-HYAL-1 antibody were used for hyaluronic acid and HYAL-1 staining, respectively. Staining was graded between 0 and 300 depending on staining intensity and area. Results: HYAL-1 and hyaluronic acid were expressed in tumor cells and stroma, respectively. In biopsy specimens HYAL-1 and hyaluronic acid expression was higher in group 1 than in group 2 (203.9 and 182.1 vs 48.8 and 87.0, respectively, p <0.0001). On univariate analysis hyaluronic acid, HYAL-1, biopsy Gleason and prostate specific antigen significantly predicted biochemical recurrence (p <0.001). On multivariate analysis only HYAL-1 staining independently predicted recurrence with an accuracy of 81.8% (p <0.001). In prostatectomy specimens only HYAL-1 staining correlated with staining in biopsy specimens (Spearman ρ = 0.72, p = 0.0002) and predicted biochemical recurrence. Conclusions: To our knowledge this is the first report that HYAL-1 staining in biopsy specimens is an independent predictor of biochemical recurrence. This may be useful when selecting treatment. References 1 : EAU guidelines on prostate cancer. Eur Urol2008; 53: 68. Google Scholar 2 : Therapeutic options for hormone-refractory prostate cancer in 2007. Urol Oncol2007; 25: 413. Google Scholar 3 : Hyaluronan in human tumors: pathobiological and prognostic messages from cell-associated and stromal hyaluronan. Semin Cancer Biol2008; 18: 288. Google Scholar 4 : Hyaluronan and hyaluronidase in genitourinary tumors. Front Biosci2008; 13: 5664. Google Scholar 5 : Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44. Cancer Res2008; 68: 483. 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Link, Google Scholar © 2009 by American Urological AssociationFiguresReferencesRelatedDetailsRelated articlesJournal of Urology17 Aug 2009Periprostatic Adipose Tissue as a Modulator of Prostate Cancer AggressivenessJournal of Urology17 Aug 2009Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis Volume 182Issue 4October 2009Page: 1350-1356 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordshyaluronic acidhyaluronoglucosaminidaseneoplasm recurrenceprostatic neoplasmsprostateMetricsAuthor Information Christopher S. Gomez Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Equal study contribution. More articles by this author Pablo Gomez Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Equal study contribution. More articles by this author Judith Knapp Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Department of Urology, Eberhard-Karls-University, Tübingen, Germany More articles by this author Merce Jorda Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida More articles by this author Mark S. Soloway Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida More articles by this author Vinata B. Lokeshwar Department of Urology, University of Miami Miller School of Medicine, Miami, Florida Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, Florida More articles by this author Expand All Advertisement PDF downloadLoading ...