Stereochemical studies of the formation of chiral internucleotide linkages by phosphoramidite coupling in the synthesis of oligodeoxyribonucleotides
1984; Elsevier BV; Volume: 25; Issue: 46 Linguagem: Inglês
10.1016/s0040-4039(01)81583-5
ISSN1873-3581
Autores Tópico(s)Synthesis of Tetrazole Derivatives
ResumoHPLC-fractionated (Rp)- and (Sp)-phosphoramidites underwent tetrazole-catalyzed coupling to support-bound nucleosides to give intermediary phosphates with epimerization at phosphorus, as shown by conversion to epimerized mixtures of dinucleoside phosphorothioates.
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