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Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice

2010; Elsevier BV; Volume: 83; Issue: 1-2 Linguagem: Inglês

10.1016/j.brainresbull.2010.05.011

1873-2747

Francisca Charliane Carlos da Silva, Maria do Carmo de Oliveira Citó, Maria Izabel Gomes da Silva, Brinell Arcanjo Moura, Manuel Rufino de Aquino Neto, Mariana Lima Feitosa, Raquell de Castro Chaves, Danielle S. Macêdo, Silvânia Maria Mendes Vasconcelos, Marta Maria de França Fonteles, Francisca Cléa Florenço de Sousa,

Stress Responses and Cortisol

A growing body of evidence has pointed to the ionotropic glutamate N-methyl-d-aspartate receptor (NMDA) as an important player in the etiology of psychopathologies, including anxiety and major depression. Clinical findings suggest that ketamine may be used for the treatment of major depression. There is evidence that reactive oxygen species also play an important role in the pathogenesis of many diseases, particularly those which are neurological and psychiatric in nature. This study examined the behavioral and oxidative stress alterations after a single administration of ketamine (5, 10 and 20mg/kg i.p.) in mice. Ketamine presented a significant anxiogenic effect in the elevated plus-maze model of anxiety, also increasing locomotor activity. In the forced swimming and tail suspension tests, a significant decrease in immobility time after ketamine administration was observed. In addition to the behavioral changes induced by ketamine, this drug also increased lipid peroxidation, nitrite content and catalase activity, while decreased GSH levels in mice prefrontal cortex. In conclusion, our results confirm the antidepressant effects of ketamine, also showing a pro-oxidant effect of this drug.