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Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls

2002; Cambridge University Press; Volume: 181; Issue: S43 Linguagem: Inglês

10.1192/bjp.181.43.s58

1472-1465

Raimo K. R. Salokangas, Tyrone D. Cannon, Tgm van Erp, Tuula Ilonen, Tero Taiminen, Hasse Karlsson, Hannu Lauerma, Kirsi-Marja Leinonen, Elina Wallenius, A. Kalijonen, Erkka Syvälahti, Harry Vilkman, A. Alanen, Jarmo Hietala,

Functional Brain Connectivity Studies

Structural brain abnormalities are prevalent in patients with schizophrenia and affective disorders.To study how regional brain volumes and their ratios differ between patients with schizophrenia, psychotic depression, severe non-psychotic depression and healthy controls.Magnetic resonance imaging scans of the brain on first-episode patients and on healthy controls.Patients with schizophrenia had a smaller left frontal grey matter volume than the other three groups. Patients with psychotic depression had larger ventricular and posterior sulcal cerebrospinal fluid (CSF) volumes than controls. Patients with depression had larger white matter volumes than the other patients.Left frontal lobe, especially its grey matter volume, seems to be specifically reduced in first-episode schizophrenia. Enlarged cerebral ventricles and sulcal CSF volumes are prevalent in psychotic depression. Preserved or expanded white matter is typical of non-psychotic depression.