Artigo Acesso aberto Revisado por pares

Comprehensive analysis of DNA methylation data with RnBeads

2014; Nature Portfolio; Volume: 11; Issue: 11 Linguagem: Inglês

10.1038/nmeth.3115

ISSN

1548-7105

Autores

Yassen Assenov, Fabian Müller, Pavlo Lutsik, Jörn Walter, Thomas Lengauer, Christoph Bock,

Tópico(s)

Genetic Syndromes and Imprinting

Resumo

RnBeads facilitates user-friendly analysis of large-scale DNA methylation data and fosters reproducibility and data sharing. RnBeads is a software tool for large-scale analysis and interpretation of DNA methylation data, providing a user-friendly analysis workflow that yields detailed hypertext reports ( http://rnbeads.mpi-inf.mpg.de/ ). Supported assays include whole-genome bisulfite sequencing, reduced representation bisulfite sequencing, Infinium microarrays and any other protocol that produces high-resolution DNA methylation data. Notable applications of RnBeads include the analysis of epigenome-wide association studies and epigenetic biomarker discovery in cancer cohorts.

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