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Standing Frame and Electrical Stimulation Therapies Partially Preserve Bone Strength in a Rodent Model of Acute Spinal Cord Injury

2013; Lippincott Williams & Wilkins; Volume: 92; Issue: 5 Linguagem: Inglês

10.1097/phm.0b013e318287697c

1537-7385

Ariane Zamarioli, Ricardo Battaglino, Leslie R. Morse, Supreetha Sudhakar, Daniel A. Maranho, Rodrigo Okubo, José Batista Volpon, Antônio Carlos Shimano,

Cerebral Palsy and Movement Disorders

The aim of this study was to compare the effect of standing frame and electrical stimulation on bone quality in a rodent transection model of spinal cord injury (SCI).Seven-week-old male Wistar rats were divided into four groups: sham, n = 10; SCI, n = 7; SCI + standing frame, n = 7; and SCI + electrical stimulation, n = 7. Complete SCI was generated by surgical transection of the cord at the T10 level. Therapies were initiated 3 days after the surgery, 3 days/wk, 20 mins/day, for 30 days. Animals were killed on day 33 postinjury.No treatment preserved bone mineral density at any skeletal site tested (P = 0.08-0.99). Standing frame therapy preserved maximal load at the lumbar vertebral body (14% vs. 37% reduction, P = 0.01) and prevented SCI-induced loss of stiffness at both the femur (8% vs. 37% reduction, P = 0.03) and the tibia (35% vs. 56% reduction, P < 0.0001). Electrical stimulation therapy reduced SCI-induced loss of stiffness at the tibia only (40% vs. 56% reduction, P = 0.003).Standing frame and electrical stimulation may have potential as future therapeutic modalities to treat or prevent bone loss after SCI.