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Predictors of quality of life in patients with refractory mesial temporal lobe epilepsy

2012; Elsevier BV; Volume: 25; Issue: 2 Linguagem: Inglês

10.1016/j.yebeh.2012.06.037

1525-5069

Carla Pauli, Maria Emília de Oliveira Thais, Lucia Sukys-Claudino, Maria Alice Horta Bicalho, Alexandre Bastos, Ricardo Guarnieri, Jean Costa Nunes, Kátia Lin, Marcelo Neves Linhares, Roger Walz,

Neuroscience and Neuropharmacology Research

PurposeThe identification of variables associated with health-related quality of life (HRQoL) in patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) would improve surgical decision-making and post-operatory follow-up in this group of patients.MethodsWe analyzed the independent association between the Quality of Life in Epilepsy Inventory—31 (QOLIE-31) of 81 consecutive patients with refractory MTLE-HS. The clinical, demographic, radiological and electrophysiological variables were analyzed by multiple linear regression analysis.Key findingsApproximately 36% (adjusted R2=0.36; R coefficient=0.66) of the QOLIE-31 overall score variance was explained by the history of initial precipitant injury, family history of epilepsy, disease duration, age of epilepsy onset, seizure frequency and presence of psychiatric axis-II diagnosis. The variance of QOLIE‐31 sub-scales was: seizure worry=7%; overall QOL=11%; emotional well‐being=32%; energy/fatigue=38%; cognitive function=13%; medication effects=7%; social function=13% (R coefficient between 0.30 and 0.65).SignificanceThe pre-surgical variables studied had relatively low prediction capacity for the overall QOLIE-31 score and its sub-scales in this set of Brazilian patients with refractory MTLE‐HS.